Functionalized nanofibers mat prepared through thiol-ene "click" reaction as solid phase extraction adsorbent for simultaneous detection of florfenicol and paracetamol residues in milk.

Journal: Food chemistry
Published Date: Oct 21, 2023

Abstract

Due to the significant differences in physical and chemical properties of various veterinary drugs, sample pretreatment is still the bottleneck of simultaneous detection of multiple veterinary drug residues. In order to achieve quantitative determination of two different types of veterinary drug residues (florfenicol and paracetamol) in milk, 1-allyl-3-methylimidazolium chloride (AmimCl) functionalized nanofibers mat (AmimCl-NFsM) was prepared through thiol-ene "click" reaction and applied as a new solid phase extraction adsorbent. The preparation parameters were systematically investigated and optimized through dynamic adsorption experiments. The developed method achieved significant extraction and purification efficiency, which was attributed to the multiple adsorption mechanisms of AmimCl-NFsM. Under the optimal condition, the established method showed low detection limit (1.25-2.90 ng/mL), high precision (RSDs ≤ 12.6 %) and good recovery (76.4 %-96.1 % with RSDs ≤ 5.23 %). The obtained results demonstrated the practical application value of the established method in food safety field.

Authors

  • Yumo Chen
    Hebei Key Laboratory of Public Health Safety, College of Public Health, School of Life Sciences, Hebei University, Baoding 071002, China.
  • Jiankun Cao
    Hebei Key Laboratory of Public Health Safety, College of Public Health, School of Life Sciences, Hebei University, Baoding 071002, China; State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China. Electronic address: jkyj0812@hbu.edu.cn.
  • Jie Zhang
    College of Physical Education and Health, Linyi University, Linyi, Shandong, China.
  • Zhezhe Qi
    State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
  • Hongyuan Yan
    Hebei Key Laboratory of Public Health Safety, College of Public Health, School of Life Sciences, Hebei University, Baoding 071002, China; State Key Laboratory of New Pharmaceutical Preparations and Excipients, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.

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