Disruption of parkinsonian brain oscillations
Journal:
arXiv
Published Date:
Jun 18, 2025
Abstract
Deep brain stimulation (DBS) is an advanced surgical treatment for the
symptoms of Parkinson's disease (PD), involving electrical stimulation of
neurons within the basal ganglia region of the brain. DBS is traditionally
delivered in an open-loop manner using fixed stimulation parameters, which may
lead to suboptimal results. In an effort to overcome these limitations, closed
loop DBS, using pathological subthalamic beta (13--30 Hz) activity as a
feedback signal, offers the potential to adapt DBS automatically in response to
changes in patient symptoms and side effects. However, clinically implemented
closed-loop techniques have been limited to date to simple control algorithms,
due to the inherent uncertainties in the dynamics involved. Model-free control,
which has already seen successful applications in the field of bioengineering,
offers a way to avoid this limitation and provides an alternative method to
apply modern control approach to selective suppression of pathological
oscillations.
