Trimester-specific exposure to triclocarban during pregnancy: Associations with oxidative stress and size at birth.

Journal: The Science of the total environment
Published Date: Oct 27, 2023

Abstract

Triclocarban (TCC) is an extensively used antimicrobial agent that exhibits endocrine disrupt potential, but its effects on fetal growth remain largely unknown. Herein, we measured TCC, its four hydroxylated metabolites and two dechlorination products, as well as the oxidative stress biomarker 8-hydroxy-2'-deoxyguanosine (8-OHdG) in maternal urine samples collected across three trimesters of pregnancy in Wuhan, China. Linear mixed-effect models and multiple linear regression models were applied for correlation analysis. TCC was detected in >97 % of urine samples after conjugate hydrolysis (geometric mean: 0.249-0.335 ng/mL). An interquartile range increase in TCC was associated with a 6.65 % increase in 8-OHdG (95 % confidence interval: 2.15-11.16 %). Urinary TCC in the first trimester was inversely associated with body weight in infant girls, with significant p-value for trend (p = 0.011) across tertiles of TCC concentrations. Urinary 8-OHdG in the third trimester was associated with reduced ponderal index in infant boys (p = 0.020). Urinary levels of TCC correlated well with its transformation products (2'-OH-TCC, 3'-OH-TCC, 6-OH-TCC, 4'-DHC, and DCC). No clear association was found between these metabolites and 8-OHdG, as well as size at birth. Our results revealed the potential exposure risks of TCC during the early life stage, future replications in other populations are needed.

Authors

  • Hongna Zhang
    Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, China; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong 999077, China.
  • Qiong Luo
    State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong 999077, China.
  • Chengchen Hu
    Department of Stomatology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Qian Song
    Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, China.
  • Yanqiu Zhou
    State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong 999077, China; Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Xiuli Su
    State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong 999077, China.
  • Yuanyuan Li
    Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wei Xia
    Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yuxin Zheng
    Department of Occupational and Environmental Health, School of Public Health, Qingdao University, Qingdao 266071, China.
  • Shunqing Xu
    School of Life Sciences, Hainan University, Haikou, Hainan 570228, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xust@hust.edu.cn.
  • Zongwei Cai
    State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong 999077, China. Electronic address: zwcai@hkbu.edu.hk.

Keywords

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