HelixDesign-Antibody: A Scalable Production-Grade Platform for Antibody Design Built on HelixFold3
Journal:
arXiv
Published Date:
Jul 3, 2025
Abstract
Antibody engineering is essential for developing therapeutics and advancing
biomedical research. Traditional discovery methods often rely on time-consuming
and resource-intensive experimental screening. To enhance and streamline this
process, we introduce a production-grade, high-throughput platform built on
HelixFold3, HelixDesign-Antibody, which utilizes the high-accuracy structure
prediction model, HelixFold3. The platform facilitates the large-scale
generation of antibody candidate sequences and evaluates their interaction with
antigens. Integrated high-performance computing (HPC) support enables
high-throughput screening, addressing challenges such as fragmented toolchains
and high computational demands. Validation on multiple antigens showcases the
platform's ability to generate diverse and high-quality antibodies, confirming
a scaling law where exploring larger sequence spaces increases the likelihood
of identifying optimal binders. This platform provides a seamless, accessible
solution for large-scale antibody design and is available via the antibody
design page of PaddleHelix platform.
