In Vitro Antibacterial and Antibiofilm Activities of L. Ethanolic Leaf Extract on ATCC 29213.

Journal: Acta medica Philippina
Published Date: Dec 18, 2023

Abstract

BACKGROUND AND OBJECTIVE: Staphylococcus aureus is the leading cause of skin and soft tissue infections such as abscesses, furuncles, and cellulitis. Biofilm forming strains of have higher incidence of antimicrobial resistance to at least three or more antibiotics and are considered as multidrug resistant. Since biofilm-producing strains have higher rates of multidrug and methicillin resistance compared to non-biofilm-producing strains, the need for alternative therapeutic option is important. Furthermore, rates of methicillin-resistant (MRSA) in Asia remain high. Results of the study may provide support for the clinical uses of as a topical antibacterial and antiseptic in the treatment and prevention of infections involving the skin, mouth, throat, and indwelling medical devices. Thus, this study aimed to evaluate the in vitro antibacterial and antibiofilm activities of L. ethanolic leaf extract (PBE) against a biofilm-forming methicillin-sensitive ATCC 29213 (MSSA).

Authors

  • Ryan Christopher C Lao
    Department of Pharmacology and Toxicology, College of Medicine, University of the Philippines Manila.
  • Ailyn M Yabes
    Department of Pharmacology and Toxicology, College of Medicine, University of the Philippines Manila.
  • Marohren Tobias-Altura
    Department of Medical Microbiology, College of Public Health, University of the Philippines Manila.
  • Lynn Crisanta R Panganiban
    Department of Pharmacology and Toxicology, College of Medicine, University of the Philippines Manila.
  • Irma R Makalinao
    Department of Medical Microbiology, College of Public Health, University of the Philippines Manila.

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