Serum Concentration of MMP-9 as a Predictive Biomarker for the Progression of Oral Cancer.

Journal: Journal of maxillofacial and oral surgery
Published Date: May 12, 2023

Abstract

BACKGROUND: Oral cancer is the most prominent cancer subtype among all head and neck cancers, the incidence and prevalence of which has been consistently increasing in past years around the globe. At advanced stages, oral cancer imparts significant mortality, morbidity, and mutilation among the patients, and therefore, diagnosis and treatment of the disease at early stages are considered the optimum strategy for the management of the disease. Since molecular changes appear earlier than physical symptoms, several molecular biomarkers are currently being investigated for their role in diagnosing and treating disease. MMP-9 belongs to the family of proteinases that are involved in cytoskeletal degradation, which is a crucial phase of cancer progression.

Authors

  • Jyoti Saini
    Department of Otolaryngology and Head Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Jaimanti Bakshi
    Department of Otolaryngology and Head Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Naresh K Panda
    Department of Otolaryngology and Head Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Maryada Sharma
    Department of Otolaryngology and Head Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Ashok K Yadav
    Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Kajal Kamboj
    Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Atul Kumar Goyal
    Department of Otolaryngology and Head Neck Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Keywords

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