Evaluating peer-to-peer bioinformatics education: a case study of student learning outcomes and community impact in an undergraduate multi-omic data analysis course

Computational methodology has become ubiquitous in biomedical research with the rise of big data analysis and popularity of artificial intelligence and machine learning. However, undergraduate bioinformatics education has largely struggled to keep pace with the demand for bioinformatics skills, due to a combination of social and resource-based barriers. In this case study, we discuss the application and outcomes of Multi-Omic Data Analysis, a peer-to-peer learning-based undergraduate bioinformatics course offered by the Department of Quantitative and Computational Biology at the University of Southern California. Over eight semesters, a cohort of student instructors taught 2-3 weekly lectures to 107 undergraduate students in the Quantitative Biology Bachelor of Science degree program. Lectures covered a range of topics, including R and Python data analysis, scientific communication, and general research readiness as undergraduate students. We find that bioinformatics education courses structured around peer-to-peer learning have great potential to overcome many of the obstacles to comprehensive undergraduate bioinformatics education, and provide additional benefits related to student cohesion and community. We further discuss the longevity and feasibility of such courses, both specific to our program and in undergraduate universities at large. There is a growing need for accessible and beginner-friendly bioinformatics education at the undergraduate level. Traditional coursework often fails to meet this demand due to disciplinary separation between biology and computer science, as well as limited institutional resources. We evaluate a unique approach involving a student-led undergraduate bioinformatics course at the University of Southern California to understand how peer-to-peer learning influences student development in computational biology. We examined over 100 students across eight academic semesters. Students varied in prior coding experience and research exposure. Through survey responses, we found that students left the course feeling more confident and prepared for research in faculty labs. Students reported improved competence in bioinformatics skills compared to before they took the course. We found that a major reason for this success was the peer-to-peer learning format. Students mentioned that learning from fellow students made the material more approachable and created a supportive community where they felt comfortable asking questions. Our work demonstrates that student-led initiatives can be a highly effective solution for filling critical gaps in university curricula, making bioinformatics education more accessible.