Effectiveness of Nicotinamide Phosphoribosyltransferase/Pre-B Cell Colony-enhancing Factor/Visfatin in preventing High Glucose-induced Neurotoxicity in an In-vitro Model of Diabetic Neuropathy.

Journal: Basic and clinical neuroscience
Published Date: Nov 1, 2023

Abstract

INTRODUCTION: Diabetic neuropathy is a well-known complication of diabetes. Recently, hyperglycemia-induced toxicity has been confirmed to participates in multiple cellular pathways typical for neural deterioration. Nicotinamide phosphoribosyltransferase/pre-b cell colony-enhancing factor (Nampt/PBEF)/visfatin is a novel endogenous ligand that some studies have shown its neuroprotective effects on neurodegenerative disease. Therefore, we hypothesized that visfatin may prevent high glucose (HG)-induced neurotoxicity by inhibiting apoptosis, autophagy, and reactive oxygen species (ROS) responses properly.

Authors

  • Sarvin Jahanbani
    Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Mehdi Khaksari
    Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Fatemeh Sadat Bitaraf
    Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Majid Rahmati
    Cancer Prevention Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Kobra Foroughi
    Student Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.
  • Asghar Shayannia
    Department of Medical Biotechnology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran.

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