Determination of ertapenem in plasma and ascitic fluid by UHPLC-MS/MS in cirrhotic patients with spontaneous bacterial peritonitis.

Journal: Advances in laboratory medicine
Published Date: Dec 20, 2023

Abstract

OBJECTIVES: Spontaneous bacterial peritonitis is a frequent severe complication in cirrhotic patients with ascites. Carbapenem antibiotics are currently the treatment of choice for patients with hospital-acquired or healthcare-related infections. However, there is limited evidence available on the efficacy of ertapenem in cirrhotic patients with spontaneous bacterial peritonitis. As a result, the pharmacokynetics and pharmacodynamics of this antibiotic are still unknown. The objective of this study was to develop and validate measurement procedures based on liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to determine ertapenem concentrations in plasma and ascitic fluid.

Authors

  • Raúl Rigo-Bonnin
    Clinical Laboratory, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • Alberto Amador
    Service of Pharmacy, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • María Núñez-Gárate
    Clinical Laboratory, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • Virgínia Mas-Bosch
    Clinical Laboratory, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • Ariadna Padullés
    Unit of Hepatology and Liver Transplant, Service of Gastroenterology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • Sara Cobo-Sacristán
    Unit of Hepatology and Liver Transplant, Service of Gastroenterology, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • José Castellote
    Service of Pharmacy, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.

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