Transforming Biospecimen Management: A Roadmap for Integrated Sample Traceability in the Era of Global Research.

Journal: Biopreservation and biobanking
Published Date: Feb 19, 2026

Abstract

INTRODUCTION: Advancements in biomedical research depend on the quality and availability of biological samples. Despite their sophisticated storage capabilities, biobanks face significant challenges in sample management, with stored specimens often remaining unused and researchers struggling to access the required samples. OBJECTIVES: To analyze the challenges in biospecimen access and traceability, evaluate existing solutions, and propose a framework for integrated sample management in global research collaboration. METHODS: A scoping review was conducted across PubMed, Scopus, and Web of Science databases, supplemented by grey literature (2004-2024). The analysis included an examination of Biobank Information Management Systems and an evaluation of sample management systems, tracking technologies, and governance frameworks. RESULTS: The analysis revealed fragmented management systems, with at least 38 different biobanking software solutions offering limited interoperability. Proprietary systems and vendor lock-ins create significant barriers to data sharing. Sample tracking shows the evolution from manual to digital systems; however, cross-institutional tracking remains challenging. Reproducibility issues account for significant challenges in research, whereas inefficient resource utilization persists, with 67% of biobanks citing underutilization as a major concern. CONCLUSIONS: Addressing biobank sample access and traceability requires a shift from an institution-centric to an ecosystem-wide approach. Its success depends on integrating technological solutions such as Blockchain, the Internet of Things, and artificial intelligence with governance frameworks while ensuring alignment with stakeholder needs. Future developments should focus on implementing integrated traceability systems that support transparent and accountable sample management across the global research ecosystem.

Authors

  • Sion Israel Sion
    Software and IT Engineering Department, École de Technologie Supérieure, Montreal, Canada.
  • Trinh Nguyen-Phan
    The University of British Columbia School of Library Archival and Information Studies, Vancouver, Canada.
  • Mélissa Fortin
    École des Sciences de la gestion (ESG) Université du Québec à Montréal, Montréal, Canada.
  • Anne-Marie Mes-Masson
    Centre de recherche du Centre, Hospitalier de l'Université de Montréal, Montréal, Canada.
  • Kaiwen Zhang
    Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

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