Recent advances in spectroscopic chiral analysis of carboxylic acids.

Carboxylic acids are fundamental to cellular metabolism and hold broad significance across pharmaceuticals, life science, food science, and agrochemicals. The inherent chirality of many carboxylic compounds profoundly influences their physicochemical properties, biological activity, and therapeutic potential, underscoring the need for rapid and accurate enantiomeric analysis. In recent years, substantial progress has been made in developing and refining analytical strategies for chiral discrimination of carboxylic acids. This review highlights key advancements since 2019, with a particular focus on spectroscopic approaches, NMR, circular dichroism (CD), and fluorescence spectroscopy, as well as mass spectrometry (MS). We also discuss how artificial intelligence (AI) is increasingly supporting and enhancing these analytical methods. By surveying these developments, the review aims to provide researchers with a comprehensive overview of emerging methodologies and their applications in chiral analysis.