Methotrexate-induced hepatotoxicity in rats and the therapeutic properties of vitamin E: a histopathologic and flowcytometric research.

Journal: Clinical and experimental hepatology
Published Date: Oct 27, 2023

Abstract

AIM OF THE STUDY: Methotrexate (MTX) causes oxidative stress-related liver damage. Our objective was to investigate the protective effects of vitamin E against MTX-induced hepatotoxicity through histopathological methods and flow cytometry.

Authors

  • Ahmet U Akman
    Department of Histology and Embryology, Faculty of Medicine, Amasya University, Turkey.
  • Zuleyha Erisgin
    Department of Histology and Embryology, Faculty of Medicine, Giresun University, Turkey.
  • Sibel Turedi
    Department of Histology and Embryology, Faculty of Medicine, Harran University, Turkey.
  • Yavuz Tekelioglu
    Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, Turkey.

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