Deep learning as a generator of sodium channel state hypotheses.
Journal:
The Journal of general physiology
Published Date:
Mar 10, 2026
Abstract
Lopez-Mateos et al. show that AlphaFold 2 can generate structural ensembles of NaV channels and that β-subunits and calmodulin reshape these ensembles, while emphasizing that these are testable structural hypotheses, not actual thermodynamic populations.
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