Decoding and deciphering a subcellular ZIP code system.

Proteins contain unique sequences that direct localization within cells, forming a subcellular 'ZIP code' system. Kilgore et al. recently developed an artificial intelligence/machine learning (AI/ML) approach for predicting protein subcellular localization. Internalizing phage display, together with other current experimental methods, may be applicable alongside AI/ML approaches for profiling the subcellular ZIP code system.