Pharmacokinetics evaluation of newly formulated beads alginate/gum acacia loaded ketoconazole in rabbit plasma by oral administration.

Journal: ADMET & DMPK
Published Date: Nov 30, 2023

Abstract

BACKGROUND AND PURPORSE: The combination of alginate and gum acacia in previous studies showed good results in inhibiting ketoconazole precipitation due to the supersaturation phenomenon. Ketoconazole-loaded alginate and gum acacia can produce hydrogel beads through cross-linking with Ca using ionotropic gelation techniques. However, the pharmacokinetic study of the ketoconazole beads loaded to alginate and gum acacia needs further investigation. This study aimed to evaluate pharmacokinetic parameters using rabbits via oral administration.

Authors

  • Viviane Annisa
    Program Doctoral Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.
  • Teuku Nanda Saifullah Sulaiman
    Departement of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.
  • Akhmad Kharis Nugroho
    Departement of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.
  • Agung Endro Nugroho
    Departement of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Indonesia.

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