Consumption of Reinforcing Solutions Engages Dynamic Activityof the Prelimbic Cortical Outputs

Journal: bioRxiv
Published Date: Mar 12, 2026

Abstract

The medial prefrontal cortex integrates information about salience and valence of stimuli, including rewarding solutions like alcohol and sucrose, and regulates aspects of alcohol seeking and consumption. However, our understanding of how cortical outputs encode alcohol consumption is limited. Using fiber photometry to measure calcium activity in putative prelimbic (PrL) glutamatergic projection neurons, we show similar but distinct patterns of activity during the peri-consummatory phase in response to consumption of water (non-deprived conditions), ethanol (20% v/v), or sucrose (1% w/v). PrL population activity appears to track hedonic value, as GCaMP6f signals ramped immediately preceding bouts for water, ethanol, and sucrose, and the signal scaled with presumed hedonic value, i.e., water

Authors

  • Rinker
  • J. A.; Kutlu
  • M. G.; Knapp
  • J.; Hoffman
  • M.; Wukitsch
  • T. J.; Calipari
  • E. S.; McMahan
  • C. S.; Baker
  • G. H.; Woodward
  • J. J.; Mulholland
  • P. J.

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