MicroRNA-30a inhibits cell proliferation in a sepsis-induced acute kidney injury model by targeting the YAP-TEAD complex.

Journal: Journal of intensive medicine
Published Date: Oct 11, 2023

Abstract

BACKGROUND: Acute kidney injury (AKI) is a primary feature of renal complications in patients with sepsis. MicroRNA (miRNA/miR)-30a is an essential regulator of cardiovascular diseases, tumors, phagocytosis, and other physical processes, but whether it participates in sepsis-induced AKI (sepsis-AKI) is unknown. We aimed to elucidate the functions and molecular mechanism underlying miR-30a activity in sepsis-AKI.

Authors

  • Junfeng Su
    Department of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
  • Ying Wang
    Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
  • Jing Xie
    Department of Critical Care Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Long Chen
    Department of Critical Care Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Xinxin Lin
    Department of Critical Care Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Jiandong Lin
    Department of Critical Care Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.
  • Xiongjian Xiao
    Department of Critical Care Medicine, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

Keywords

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