The Application of Radiomics in Laryngeal Cancer Management: A Scoping Review of the Literature.

Journal: The Laryngoscope
Published Date: Oct 16, 2025

Abstract

OBJECTIVE: Laryngeal cancer is a significant head and neck malignancy, whose prevalence is increasing. Radiomics consists of high-dimensional and reproducible quantitative data which can serve as biomarkers with strong correlations to tumor staging, prognosis, and survival outcomes. The aim of this scoping review is to summarize the knowledge from the existing literature regarding the value of radiomics in laryngeal cancer management. DATA SOURCES: Eligible articles were identified by a search of the Medline and PubMed bibliographical databases for the period up to May 2025. REVIEW METHODS: This scoping review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The methodological quality of the included studies was assessed using the Radiomics Quality Score (RQS) framework. RESULTS: Thirty studies were deemed eligible, including a total of 3503 patients with laryngeal cancer. Primary objectives were the development of predictive models for overall survival, progression-free survival, local control, treatment response, and staging. Across studies, radiomics-based models consistently outperformed clinical or conventional imaging-based models in predicting key outcomes. Models combining radiomic features with clinicopathological variables achieved the highest accuracy. Recent advances include the use of deep learning, which further improved predictive performance compared to traditional radiomics. However, common limitations include heterogeneity in imaging protocols, feature extraction software, and model development algorithms, as well as a lack of external validation. CONCLUSION: Despite several limitations that currently hinder routine clinical adoption of radiomics, this rapidly evolving field demonstrates significant potential to improve staging accuracy, prognostication, and personalized management in laryngeal cancer.

Authors

  • Anna-Maria Papadopoulou
    "G. Gennimatas" General Hospital of Athens, Athens, Greece.
  • George K Matsopoulos
    Biomedical Engineering Laboratory, School of Electrical and Computer Engineering, National Technical University of Athens, 15780 Athens, Greece.
  • Vassilis Kouloulias
    2nd Department of Radiology, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Efthymios Kyrodimos
    First ENT Department, Hippocration Hospital, National Kapodistrian University of Athens, Athens, GR 11527, Greece.
  • Sotirios Papouliakos
    "G. Gennimatas" General Hospital of Athens, Athens, Greece.
  • Olga Menegaki
    Biomedical Engineering Laboratory, Department of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.
  • Theodore L Economopoulos
    Department of Electrical and Computer Engineering, National Technical University of Athens, 15780, Athens, Greece.
  • Ilias Lazarou
    2nd ENT Department, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Alexander Delides
    2nd ENT Department, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

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