Development and internal validation of machine learning-based models and external validation of existing risk scores for outcome prediction in patients with ischaemic stroke.

Journal: European heart journal. Digital health
Published Date: Nov 22, 2023

Abstract

AIMS: We developed new machine learning (ML) models and externally validated existing statistical models [ischaemic stroke predictive risk score (iScore) and totalled health risks in vascular events (THRIVE) scores] for predicting the composite of recurrent stroke or all-cause mortality at 90 days and at 3 years after hospitalization for first acute ischaemic stroke (AIS).

Authors

  • Daniel Axford
    Department of Information Technology, Mathematics and Statistics, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Australia.
  • Ferdous Sohel
    Department of Information Technology, Mathematics and Statistics, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Australia.
  • Vida Abedi
    Department of Public Health Science, Penn State College of Medicine, Hershey, PA, USA.
  • Ye Zhu
    Phase I Clinical Trial Site, Nanjing Gaoxin Hospital, Nanjing, Jiangsu, China.
  • Ramin Zand
    Neuroscience Institute, Geisinger Health System, 100 North Academy Ave, Danville, PA 17822, USA.
  • Ebrahim Barkoudah
    Internal Medicine/Hospital Medicine, Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
  • Troy Krupica
    Internal Medicine/Hospital Medicine, West Virginial University, Morgantown, WV, USA.
  • Kingsley Iheasirim
    Internal Medicine/Hospital Internal Medicine, Mayo Clinic Health System, Mankato, MN, USA.
  • Umesh M Sharma
    Hospital Internal Medicine, Mayo Clinic, Phoenix, AZ, USA.
  • Sagar B Dugani
    Hospital Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Paul Y Takahashi
    Community Internal Medicine, Mayo Clinic, Rochester, MN, USA.
  • Sumit Bhagra
    Endocrinology, Diabetes and Metabolism, Mayo Clinic Health System, Austin, MN, USA.
  • Mohammad H Murad
    Division of Public Health, Infectious Diseases, and Occupational Medicine, Mayo Clinic, Rochester, MN, USA.
  • Gustavo Saposnik
    Stroke Outcomes and Decision Neuroscience Research Unit, Division of Neurology, Department of Medicine and Li Ka Shing Knowledge Institute, St.Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
  • Mohammed Yousufuddin
    Hospital Internal Medicine, Mayo Clinic Health System, 1000 1st Drive NW, Austin, MN 55912, USA.

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