Clinically aligned rationale generation for glaucoma subtype classification via a knowledge-distilled language model
Journal:
medRxiv
Published Date:
Jun 26, 2026
Abstract
Automated glaucoma subtype classification from clinical notes remains clinically unactionable without subspecialty-aligned explanations supporting clinician-facing deployment. We extended our Ci-SSGAN with a GPT-5.2-to-Qwen3-8B teacher-distilled reasoning module, fine-tuning Qwen3-8B on 2,660 de-identified ophthalmology notes using expert-reviewed rationales. On 294 notes, the fine-tuned model achieved ROUGE-L 0.792 and BERTScore F1 0.955, surpassing eight zero-shot comparators including GPT-4o and GPT-4.1, establishing privacy-preserving distillation as a path to interpretable AI.
