Screening and Identification of DNA Nanostructure Aptamer Using the SELEX Method for ‎Detection of Epsilon Toxin.

Journal: Iranian journal of pharmaceutical research : IJPR
Published Date: Dec 8, 2023

Abstract

BACKGROUND: Epsilon toxin (ETX), produced by , is one of the most potent toxins known, with a lethal potency approaching that of botulinum neurotoxins. Epsilon toxin is responsible for enteritis. Therefore, the development of rapid and simple methods to detect ETX is imperative. Aptamers are single-stranded oligonucleotides that can bind tightly to specific target molecules with an affinity comparable to that of monoclonal antibodies (mAbs). DNA aptamers can serve as tools for the molecular identification of organisms, such as pathogen subspecies.

Authors

  • Nafiseh Shafiei
    Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
  • Hamideh Mahmoodzadeh Hosseini
    Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Jafar Amani
    Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Seyed Ali Mirhosseini
    Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Hanieh Jafary
    Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Keywords

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