High-performance surface plasmon resonance biosensor design: Encircled quad-block resonator structure for real-time label-free detection of marijuana assisted with linear regression.

In the last few years, chemical analysis and chromatography approaches have been implemented widely for detecting marijuana. Such approaches are slightly unreliable, which may consume considerable time, demand a lot of money, and depend on specific laboratory tools. The increasing need for swift, lightweight, and straightforward methods of identification has led to investigations into biosensor devices that offer immediate analysis and greater sensitivity. To fulfil this need, we have hypothesized a novel design of an Encircled Quad-Block Configuration Refractive Index Biosensor (EQBCRIB) has been developed for the label-free detection of marijuana in the blood. The configuration of the encircled quad-block sensor can be able to combine stability, sensitivity, and adaptability at a single platform, which can draw attention as a transformative design with the most effective of 392.49 nm/RIU, 390.69 nm/RIU, and 388.15 nm/RIU to detect MIB1 (marijuana infected blood sample 1), MIB2 (marijuana infected blood sample 2), and MIB3 (marijuana infected blood sample 3), respectively. The effective detection limits of 0.0306 RIU, and the significant figure of merit values of 18.05 RIU-1 for MIB1 have been obtained. The highest values of R2 = 0.981701, and MSE (mean square error) = 0.001423 of linear regression of machine learning have been reported to ensure high detection prediction of marijuana.