Both coiling and clipping induce the time-dependent release of endogenous neuropeptide Y into serum.

Journal: Frontiers in neurology
Published Date: Feb 14, 2024

Abstract

BACKGROUND: The vaso- and psychoactive endogenous Neuropeptide Y (NPY) has repeatedly been shown to be excessively released after subarachnoid hemorrhage and in numerous psychiatric disorders. NPY is stored in sympathetic perivascular nerve fibers around the major cerebral arteries. This prospective study was designed to analyze the impact of microsurgical and endovascular manipulation of the cerebral vasculature versus cranio- and durotomy alone on the serum levels of NPY.

Authors

  • Elisabeth Bründl
    Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.
  • Martin Proescholdt
    Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.
  • Petra Schödel
    Department of Orthopedics, Trauma and Hand Surgery, Section Neurosurgery, Medical Center St. Elisabeth, Straubing, Germany.
  • Katharina Rosengarth
    Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.
  • Eva-Maria Störr
    Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.
  • Sylvia Bele
    Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.
  • Martin Kieninger
    Department of Anesthesiology, University Medical Center Regensburg, Regensburg, Germany.
  • Manuela Malsy
    Department of Anesthesiology, University Medical Center Regensburg, Regensburg, Germany.
  • Nils Ole Schmidt
    Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.
  • Karl-Michael Schebesch
    Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany.

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