Does AI know how to choose wisely? Do not trust and definitely verify when using generative AI in stewardship operations.

Antimicrobial stewardship programs (ASP) serve as a valuable resource to healthcare institutions. This commentary explores a real world demonstration of the potential advantages and pitfalls of using artificial intelligence (AI) in ASP, both in supporting the development of institutional guidelines and in providing a cost-effectiveness analysis of these protocols, as well as the caution that should be exercised when involving AI in stewardship.