Unsupervised machine learning models reveal predictive clinical markers of glioblastoma patient survival using white blood cell counts prior to initiating chemoradiation.

Journal: Neuro-oncology advances
Published Date: Nov 11, 2023

Abstract

BACKGROUND: Glioblastoma is a malignant brain tumor requiring careful clinical monitoring even after primary management. Personalized medicine has suggested the use of various molecular biomarkers as predictors of patient prognosis or factors utilized for clinical decision-making. However, the accessibility of such molecular testing poses a constraint for various institutes requiring identification of low-cost predictive biomarkers to ensure equitable care.

Authors

  • Wesley Wang
    Department of Pathology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Zeynep Temerit Kumm
    Department of Pathology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Cindy Ho
    Department of Pathology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Ideli Zanesco-Fontes
    Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
  • Gustavo Texiera
    Department of Pathology, Barretos Cancer Hospital, Barretos, Brazil.
  • Rui Manuel Reis
    Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
  • Horacio Martinetto
    Departamento de Neuropatología y Biología Molecular, Instituto de Investigaciones Neurológicas Dr Raúl Carrea (FLENI), Buenos Aires, Argentina.
  • Javaria Khan
    Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Martin G McCandless
    Department of Neuro-Oncology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Katherine E Baker
    Department of Neuro-Oncology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Mark D Anderson
    Department of Neuro-Oncology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Muhammad Omar Chohan
    Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi, USA.
  • Sasha Beyer
    Department of Radiation Oncology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • J Brad Elder
    Department of Neurosurgery, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • Pierre Giglio
    Department of Neurology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
  • José Javier Otero
    Department of Pathology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

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