Harnessing Transfer Learning for Dementia Prediction: Leveraging Sex-Different Mild Cognitive Impairment Prognosis.

Journal: Proceedings. IEEE International Conference on Bioinformatics and Biomedicine
Published Date:

Abstract

This paper presents a machine learning-based prediction for dementia, leveraging transfer learning to reuse the knowledge learned from prediction of mild cognitive impairment, a precursor of dementia. We also examine the impacts of temporal aspects of longitudinal data and sex differences. The methodology encompasses key components such as setting the duration window, comparing different modeling strategies, conducting comprehensive evaluations, and examining the sex-specific impacts of simulated scenarios. The findings reveal that cognitive deficits in females, once detected at the mild cognitive impairment stage, tend to deteriorate over time, while males exhibit more diverse decline across various characteristics without highlighting specific ones. However, the underlying reasons for these sex differences remain unknown and warrant further investigation.

Authors

  • Ziming Liu
    Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, USA.
  • Muskan Garg
    Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, USA.
  • Sunyang Fu
    Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, USA.
  • Surjodeep Sarkar
    Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, USA.
  • Maria Vassilaki
    Department of Quantitative Health Sciences, Mayo Clinic, Rochester, USA.
  • Ronald C Petersen
    Department of Neurology, Mayo Clinic, Rochester, USA.
  • Jennifer St Sauver
    Department of Quantitative Health Sciences, Mayo Clinic, Rochester, USA.
  • Sunghwan Sohn
    Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, USA.

Keywords

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