Replication and Injury Associated With SARS-CoV-2 in Cultured Hepatocytes.

Journal: Pathogens & immunity
Published Date: Feb 12, 2024

Abstract

BACKGROUND: Liver dysfunction is one of the hallmarks of SARS-CoV-2 infection. The mechanism(s) of hepatic injury in SARS-CoV-2 infection remains controversial with some reporting viral replication and cellular injury and others suggesting lack of replication and injury due to non-cytopathogenic etiologies. To investigate this further, we evaluated SARS-CoV-2 replication in immortalized hepatic cell lines and primary hepatocytes, examined whether cell injury was associated with apoptotic pathways, and also determined the effect of the antiviral remdesivir on these processes.

Authors

  • Suman Pradhan
    Department of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Susan D Rouster
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Jason T Blackard
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Gary E Dean
    Department of Molecular and Cellular Biosciences, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Kenneth E Sherman
    Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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