Susceptibility of periodontal pathogens to a novel target-specific drug delivery system containing self-nanoemulsifying curcumin: An in vitro study.

Journal: Journal of advanced periodontology & implant dentistry
Published Date: Dec 6, 2023

Abstract

BACKGROUND: Long-term use of many classic chemotherapeutic agents as adjuncts in the management of periodontitis has adverse complications, leading to seeking out naturopathic remedies. Although curcumin has been investigated in managing periodontitis, its therapeutic benefits have not been fully explored due to its limited solubility in an aqueous medium. This study aimed to develop a novel target-specific drug delivery system containing 1% self-nanoemulsifying curcumin (SNEC) in a hydroxypropylmethylcellulose (HPMC) matrix and evaluate the susceptibility of periodontal pathogens to this system in vitro.

Authors

  • Veena Hr
    Department of Periodontology, KLE Society's Institute of Dental Sciences, Bengaluru, Karnataka.
  • Riya Achamma Daniel
    Department of Dental Surgery, MIOT International, Chennai, India.
  • Ashwin Prabhu
    Department of Periodontology, KLE Society's Institute of Dental Sciences, Bengaluru, Karnataka.
  • Shilpa P
    KLE Society's Institute of Dental Sciences, Bengaluru, Karnataka.
  • Suman Basavaraju
    Department of Periodontology, JSS Dental College & Hospital, Mysuru, India.

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