Diagnostic potential of B-cell translocation gene 2 in IgA nephropathy: Insights from molecular mechanisms.

IgA nephropathy (IgAN) is a prevalent glomerular disease characterized by IgA deposition, chronic inflammation, and fibrosis, leading to end-stage renal disease. This study explored B-cell translocation gene 2 (BTG2) as a biomarker and treatment target for IgAN progression. Through integrated expression datasets and functional analyses, BTG2 emerged as a key gene with downregulation in renal tissues of IgAN patients, showing high diagnostic accuracy. BTG2 influenced the immune microenvironment by modulating T follicular helper cells and M0 macrophages. Moreover, BTG2 overexpression mitigated IgA deposition and fibrosis, whereas its silencing exacerbated these pathological changes. The study highlights BTG2 as a promising diagnostic tool and therapeutic target, shedding light on potential treatment strategies for IgAN.