Choroid plexus volume variation in patients with gliomas, glioneuronal and neuronal tumors: Associations with tumor characteristics.

PURPOSE: To investigate choroid plexus .   volume (CPV) alterations in patients with gliomas and glioneuronal and neuronal tumors (GNTs) and to evaluate their associations with tumor characteristics. METHODS: In this retrospective observational cohort study, 811 patients with histologically confirmed brain tumors (674 gliomas and 137 GNTs) and 744 controls were included. All participants underwent 3.0 T MRI with 3D T1-weighted imaging, and patient scans were acquired preoperatively. The choroid plexus was automatically segmented on 3D T1-weighted images using a 3D nnU-Net-based deep learning algorithm with expert quality control. CPV was normalized to total intracranial volume (CPV/TIV). Lateral ventricular volume (LVV) was quantified using FreeSurfer and included as a covariate. Group comparisons were performed using Mann-Whitney U and Kruskal-Wallis tests after case-control matching. Multivariable linear regression analyses were conducted to assess independent associations while adjusting for age, sex, and LVV, with additional sensitivity analyses incorporating scanner type. RESULTS: Compared with supratentorial tumors and controls, infratentorial tumors showed significantly larger CPV (both P < 0.001). Tumor grade was not independently associated with CPV after adjustment among patients. Pediatric-type diffuse high-grade gliomas and GNTs exhibited larger CPV than adult-type diffuse gliomas (P < 0.01). In exploratory molecular analyses of adult-type diffuse gliomas, + 7/ - 10 status was associated with lower CPV (β = -0.127, P = 0.009). CONCLUSION: CPV alterations in brain tumors are primarily associated with tumor location and histological classification rather than tumor grade. An exploratory association between +7/ - 10 status and lower CPV was also observed, although this finding requires further validation.