Exploring young adult cancer survivors' perspectives on generative AI chatbots for symptom support.

BACKGROUND: Young adult cancer survivors (ages 18-39) often experience persistent treatment-related symptoms that negatively affect daily functioning, psychosocial well-being, and quality of life, yet report unmet educational needs for symptom management. Generative artificial intelligence (AI) technologies, such as large language model-powered chatbots, offer scalable, personalized, and empathetic symptom support but remain largely untested in young adults' survivorship care. OBJECTIVE: This qualitative descriptive study explored young adult cancer survivors' perspectives, preferences, and experiences related to the use of generative AI chatbots for oncology symptom management. METHODS: Eighteen post-treatment young adult cancer survivors who had completed cancer treatment within the past two years were recruited from the University of Michigan Rogel Cancer Center. Participants completed the PROMIS-29, PROMIS Self-Efficacy for Managing Symptoms, and the Digital Health Literacy Scale to quantify symptom burden, self-efficacy, and digital readiness. Semi-structured interviews explored experiences with cancer treatment-related symptoms and AI use, including preferences for personalization, tone, functionality, and data governance. RESULTS: Qualitative analyses revealed three themes: (1) the need for personalized, emotionally supportive, and credible AI symptom guidance; (2) accessible and user-centered design drives engagement with AI symptom support; and (3) trust, privacy, and human oversight as preconditions for AI symptom support. Survivors viewed AI as a supplemental resource to enhance symptom monitoring, decision support, and emotional reassurance without replacing clinical care. CONCLUSION: Generative AI chatbots were perceived as acceptable and potentially valuable for AYA symptom management. Findings can guide the development of tailored digital self-management interventions responsive to the complex and evolving needs of this population.