Efficient delivery of the immunodominant genes of African swine fever virus by adeno-associated virus serotype 2.

Journal: Veterinary world
Published Date: Dec 6, 2023

Abstract

BACKGROUND AND AIM: Adeno-associated virus serotype 2 (AAV2) represents a promising basis for developing a virus-vector vaccine against African swine fever (ASF). This study aimed to create genetic constructs based on AAV2 to deliver the immunodominant genes of ASF virus (ASFV) and to evaluate their functionality . The efficiency and specificity of transgene expression, as well as their non-toxicity in cells of target animals, were evaluated.

Authors

  • Rustam Ravilov
    Kazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.
  • Antonina Galeeva
    Kazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.
  • Gennadiy Frolov
    Kazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.
  • Marina Efimova
    Kazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.
  • Elena Zakirova
    Laboratory of Regenerative Veterinary Medicine, Kazan (Volga region) Federal University, Institute of Fundamental Medicine and Biology, Kazan, Russia.
  • Albert Rizvanov
    Laboratory of Regenerative Veterinary Medicine, Kazan (Volga region) Federal University, Institute of Fundamental Medicine and Biology, Kazan, Russia.
  • Almaz Hisamutdinov
    Main Directorate of Veterinary Medicine, Ministry of the Tatarstan Republic, Kazan, Russia.
  • Lenar Garipov
    Ministry of Agriculture and Food of Tatarstan Republic, Kazan, Russia.
  • Danil Mingaleev
    Kazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.

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