Impact of Additional Administration of von Willebrand Factor Concentrates to Thrombocyte Transfusion in Perioperative Bleeding in Cardiac Surgery.

Journal: Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
Published Date: Jul 11, 2023

Abstract

BACKGROUND: Von Willebrand factor (vWF) is an important part of blood coagulation since it binds platelets to each other and to endothelial cells. In traumatic and surgical haemorrhage, both blood cells and plasmatic factors are consumed, leading to consumption coagulopathy and fluid resuscitation. This often results in large amounts of crystalloids and blood products being infused. Additional administration of vWF complex and platelets might mitigate this problem. We hypothesize that administration of vWF concentrate additionally to platelet concentrates reduces blood loss and the amount of blood products (platelets, red blood cells [RBC], fresh frozen plasma [FFP]) administered.

Authors

  • Katrin Ledergerber
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Alexa Hollinger
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Sibylle Zimmermann
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Atanas Todorov
    Cardiovascular Gender Medicine, University Hospital Zürich, Zürich, Switzerland.
  • Maren Trutmann
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Laura Gallachi
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Lena Anna Gschwandtner
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Lisa Andrea Ryser
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Caroline Eva Gebhard
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.
  • Daniel Bolliger
    Medical Faculty, University of Basel, Basel, Switzerland.
  • Andreas Buser
    Medical Faculty, University of Basel, Basel, Switzerland.
  • Dimitrios Athanasios Tsakiris
    Medical Faculty, University of Basel, Basel, Switzerland.
  • Martin Siegemund
    Intensive Care Unit, University Hospital Basel, Basel, Switzerland.

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