Chronic Stress Exposure Alters the Gut Barrier: Sex-Specific Effects on Microbiota and Jejunum Tight Junctions.

Journal: Biological psychiatry global open science
Published Date: May 8, 2023

Abstract

BACKGROUND: Major depressive disorder (MDD) is the leading cause of disability worldwide. Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants, highlighting untapped causal biological mechanisms. Dysfunction in the microbiota-gut-brain axis has been implicated in MDD pathogenesis. Exposure to chronic stress disrupts blood-brain barrier integrity; still, little is known about intestinal barrier function in these conditions, particularly for the small intestine, where absorption of most foods and drugs takes place.

Authors

  • Ellen Doney
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Laurence Dion-Albert
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Francois Coulombe-Rozon
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Natasha Osborne
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Renaud Bernatchez
    Department of Computer Science and Software Engineering and Department of Electrical and Computer Engineering, Université Laval, Québec City, Québec, Canada.
  • Sam E J Paton
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Fernanda Neutzling Kaufmann
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Roseline Olory Agomma
    Department of Computer Science and Software Engineering and Department of Electrical and Computer Engineering, Université Laval, Québec City, Québec, Canada.
  • José L Solano
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Raphael Gaumond
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Katarzyna A Dudek
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Joanna Kasia Szyszkowicz
    Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montréal, Québec, Canada.
  • Manon Lebel
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Alain Doyen
    Department of Food Science, Institute of Nutrition and Functional Foods, Université Laval, Québec City, Québec, Canada.
  • Audrey Durand
    Department of Computer Science and Software Engineering and Department of Electrical and Computer Engineering, Université Laval, Québec City, Québec, Canada.
  • Flavie Lavoie-Cardinal
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
  • Marie-Claude Audet
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Caroline Menard
    Department of Psychiatry and Neuroscience, Faculty of Medicine and CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.

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