SciFusion: Physics-Guided Compositional Diffusion for Multimodal 3D Scientific Image Generation

Existing 3D generative approaches are typically developed for individual imaging modalities, requiring substantial modality-specific data and limiting their ability to exploit shared structure across scientific imaging domains. We present SciFusion, a multimodal framework for unified 3D scientific image generation built on a latent diffusion backbone, with two key contributions. First, we introduce a compositional conditioning scheme that factorizes each modality into domain, object, and contrast representations. Sharing these factors across related modalities enables knowledge transfer across heterogeneous imaging domains and allows the factors to be recombined at inference time to synthesize unseen domain-object-contrast compositions in a zero-shot manner. Second, we incorporate domain-specific physics-informed objectives: Fourier spectral consistency for MRI, Radon projection consistency for CT, and multislice diffraction consistency for electron microscopy, to encourage generated samples to respect modality-dependent image formation processes. Extensive experiments across 15 medical and scientific imaging modalities demonstrate that SciFusion improves generation fidelity and cross-domain generalization over modality-specific and flattened multimodal conditioning strategies, while enabling zero-shot synthesis of unseen compositions without training on those target compositions. These results demonstrate that compositional, physics-guided conditioning provides a scalable framework for unified 3D scientific image generation, particularly for emerging modalities where large-scale training data are difficult to obtain.