Benchmarking Data-Free Continual Model Merging for Whole-Slide Image Survival Analysis
Journal:
arXiv
Published Date:
Oct 23, 2026
Abstract
Continual survival analysis on whole-slide images (WSIs) requires models to integrate knowledge from sequentially arriving cancer cohorts while preserving previously learned information. Model merging offers a data-free alternative by combining independently fine-tuned task experts without retaining previous training data. However, the relative behavior of different merging strategies for WSI-based survival prediction remains insufficiently understood. In this work, we establish an end-to-end benchmark for data-free continual model merging, covering task-specific fine-tuning, sequential merging, and inference under both TASK-IL and CLASS-IL settings. We systematically evaluate six representative merging strategies across four TCGA cancer cohorts and three task orders using C-index, IPCW C-index, Forgetting, and Backward Transfer under a controlled protocol. Results show that no merging strategy consistently dominates across all evaluation criteria, while censoring-aware evaluation can substantially alter the relative ranking of the compared methods. This benchmark provides a unified foundation for developing and evaluating more effective continual model merging methods for WSI-based survival analysis.