Analytical and clinical performance evaluation of enhanced chemiluminescence-based fourth-generation HIV combo assay: Report from tertiary health-care setup in North India.

Journal: Asian journal of transfusion science
Published Date: May 11, 2023

Abstract

INTRODUCTION: HIV fourth-generation assay, designed for the detection of HIV p24 antigen along with anti-HIV antibodies of both immunoglobulin M and immunoglobulin G type against HIV 1 and HIV 2 viral antigens, have helped in the early detection of HIV infection and supports in minimizing the transmission risk in the acute phase of infection. The objective of this study was to evaluate the analytical and clinical performance of HIV fourth-generation assay based on enhanced chemiluminescence technology.

Authors

  • Aseem Kumar Tiwari
    Department of Transfusion Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
  • Geet Aggarwal
    Department of Transfusion Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
  • Swati Pabbi
    Department of Transfusion Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
  • Subhasis Mitra
    Department of Transfusion Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
  • Neeti Yadav
    Department of Transfusion Medicine, Medanta - The Medicity, Gurgaon, Haryana, India.
  • Virendra Verma
    Department of Microbiology, College of Life Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India.
  • K Cheirmaraj
    Indepedent Laboratory Consultant, Chennai, Tamil Nadu, India.

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