Transient suppression of Wnt signaling in poor-quality buffalo oocytes improves their developmental competence.

Journal: Frontiers in veterinary science
Published Date: Jan 11, 2024

Abstract

INTRODUCTION: One of the most evolutionary conserved communication systems, the Wnt signaling pathway is a major gene regulatory pathway that affects the developmental competence of oocytes and regulates most embryonic developmental processes. The present study was undertaken to modulate the canonical Wnt (Wingless/integration) signaling pathway in the poor-quality (colorless cytoplasm after Brilliant Cresyl Blue staining, BCB-) buffalo cumulus-oocyte complexes (COCs) to improve their maturation (IVM) and embryo production (IVEP) rates.

Authors

  • Kriti Ahuja
    Animal Genomics Lab, Animal Biotechnology Centre, ICAR-National Dairy Research Institute, Karnal, India.
  • Vipul Batra
    Animal Genomics Lab, Animal Biotechnology Centre, ICAR-National Dairy Research Institute, Karnal, India.
  • Rakesh Kumar
    Department of Civil Engineering, National Institute of Technology Patna, India.
  • Tirtha Kumar Datta
    Animal Genomics Lab, Animal Biotechnology Centre, ICAR-National Dairy Research Institute, Karnal, India.

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