CURATE.AI-assisted dose titration for anti-hypertensive personalized therapy: study protocol for a multi-arm, randomized, pilot feasibility trial using CURATE.AI (CURATE.AI ADAPT trial).

Journal: European heart journal. Digital health
Published Date: Oct 24, 2023

Abstract

AIMS: Artificial intelligence-driven small data platforms such as CURATE.AI hold potential for personalized hypertension care by assisting physicians in identifying personalized anti-hypertensive doses for titration. This trial aims to assess the feasibility of a larger randomized controlled trial (RCT), evaluating the efficacy of CURATE.AI-assisted dose titration intervention. We will also collect preliminary efficacy and safety data and explore stakeholder feedback in the early design process.

Authors

  • Anh T L Truong
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Shi-Bei Tan
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Golda Z Wang
    Department of Pharmacy, Alexandra Hospital, Singapore 15996, Singapore.
  • Alexander W J Yip
    Department of Medicine, Alexandra Hospital, Singapore 159964, Singapore.
  • Mathias Egermark
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Wesley Yeung
    National University Heart Centre, National University Hospital Singapore, Singapore 119074, Singapore.
  • V Vien Lee
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Mark Y Chan
    National University Heart Centre, National University Hospital Singapore, Singapore 119074, Singapore.
  • Kirthika S Kumar
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Lester W J Tan
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Smrithi Vijayakumar
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Agata Blasiak
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.
  • Laureen Y T Wang
    Department of Medicine, Alexandra Hospital, Singapore 159964, Singapore.
  • Dean Ho
    The N.1 Institute for Health (N.1), National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore.

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