Myeloid differentiation factor 2 inhibitors exert protective effects on lipopolysaccharides-treated human dental pulp cells via suppression of toll-like receptor 4-mediated signaling.

Journal: Journal of dental sciences
Published Date: May 5, 2023

Abstract

BACKGROUND/PURPOSE: The toll-like receptor 4 (TLR4)-myeloid differentiation factor 2 (MD-2) complex is known to have a role in inflammation. Blocking MD-2 can suppress inflammatory process. However, the actual action of MD-2 inhibitors, including MAC28, L6H21, and 2i-10, on the inflamed human dental pulp cells (HDPCs) has never been examined. This study aims to determine the pharmacological effects of these 3 compounds on cell viability, inflammation, and osteo/odontogenic differentiation of lipopolysaccharide (LPS)-treated HDPCs.

Authors

  • Savitri Vaseenon
    Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
  • Tanida Srisuwan
    Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
  • Guang Liang
    Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Nipon Chattipakorn
    Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
  • Siriporn C Chattipakorn
    Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

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