Evaluation of Verteporfin as a Novel Antifibrotic Agent in a Rabbit Model of Glaucoma Filtration Surgery: A Pilot Study.

Journal: Ophthalmology science
Published Date: Dec 8, 2023

Abstract

PURPOSE: Verteporfin is a benzoporphyrin derivative which is Food and Drug Administration-approved for treatment of choroidal neovascularization in conjunction with photodynamic therapy. It has been shown to prevent fibrosis and scar formation in several organs and represents a promising novel antifibrotic agent for glaucoma surgery. The goal of this study is to determine the effect of verteporfin on wound healing after glaucoma filtration surgery.

Authors

  • Michelle T Sun
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
  • Renee M Cotton
    Department of Comparative Medicine, Stanford University, Palo Alto, California.
  • Chaow Charoenkijkajorn
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
  • Julian Garcia-Sanchez
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
  • Roopa Dalal
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
  • Xin Xia
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
  • Jonathan H Lin
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
  • Kuldev Singh
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
  • Jeffrey L Goldberg
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.
  • Wendy W Liu
    Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.

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