The Impact of Chronic Phthalate Exposure on Rodent Anxiety and Cognition.

Journal: Biological psychiatry global open science
Published Date: Jul 21, 2023

Abstract

BACKGROUND: There is a growing importance for environmental contributions to psychiatric disorders and understanding the impact of the exposome (i.e., pollutants and toxins). For example, increased biomonitoring and epidemiological studies suggest that daily phthalate chemical exposure contributes to neurological and behavioral abnormalities; however, these mechanisms remain poorly understood. Therefore, the current study was aimed at examining the effects of chronic phthalate exposure on rodent anxiety behaviors and cognition and the impact on hypothalamic-pituitary-adrenal axis function.

Authors

  • Zhe Yu
    Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Laxmi Iyer
    Department of Anatomy, Physiology and Genetics, Uniformed Services University Health Sciences, Bethesda, Maryland.
  • Adam P Swiercz
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
  • Elizabeth Paronett
    Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Manelle Ramadan
    Children's National Heart Institute, Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Hospital, Washington, DC.
  • Paul J Marvar
    Department of Pharmacology and Physiology, George Washington University, Washington, DC.
  • Nikki Gillum Posnack
    Department of Pharmacology and Physiology, George Washington University, Washington, DC.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals