Pharmacokinetics of florfenicol and its metabolite florfenicol amine in the plasma, urine, and feces of fattening male donkeys following single oral administration.

Journal: Frontiers in veterinary science
Published Date: Jan 4, 2024

Abstract

Florfenicol (FF) is a commonly used antibacterial agent in animals. We investigated the pharmacokinetics of FF and its metabolite florfenicol amine (FFA) in donkeys. Donkeys were administered FF (30 mg/kg bodyweight, p.o.). Pharmacokinetic parameters were calculated using a non-compartmental model. The FF (FFA) pharmacokinetics parameters were characterized by along elimination half-life () of 5.92 h (15.95 h), plasma peak concentration () of 0.13 μg/mL (0.08 μg/mL), and the time taken to reach () of 0.68 h (0.72 h). The area under plasma concentration-time curve and mean residence time of FF (FFA) in plasma were 1.31 μg·mL·h (0.47 μg·mL·h) and 10.37 h (18.40 h), respectively. The of FF and FFA in urine was 21.93 and 40.26 h, and the maximum excretion rate was 10.56 and 4.03 μg/h reached at 25.60 and 32.20 h, respectively. The respective values in feces were 0.02 and 0.01 μg·h reached at 33.40 h. The amount of FF and FFA recovered in feces was 0.52 and 0.22 μg, respectively. In conclusion, FF (FFA) is rapidly absorbed and slowly eliminated after a single oral administration to donkeys. Compared to FF, FFA was more slowly eliminated. FF (FFA) is mostly excreted through urine.

Authors

  • Shijie Liu
    Department of Chemical Engineering, SUNY College of Environmental Science and Forestry, Syracuse, NY 13210 USA.
  • Yanxin Guo
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
  • Honglei Qu
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
  • Yanjie Dong
    Shandong Academy of Agricultural Sciences, Jinan, China.
  • Shancang Zhao
    Shandong Academy of Agricultural Sciences, Jinan, China.
  • Tianze Fu
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
  • Ruifen Kang
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
  • Jie Cheng
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
  • Shimeng Huang
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
  • Lihong Zhao
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
  • Qiugang Ma
    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals