Portable Multi-focal Visual Evoked Potential Diagnostics for Multiple Sclerosis/Optic Neuritis patients.

Journal: medRxiv : the preprint server for health sciences
Published Date: Dec 26, 2023

Abstract

PURPOSE: Multiple Sclerosis (MS) is a neuro-inflammatory disease of the Central Nervous System (CNS) in which the body's immune system attacks and destroys myelin sheath that protects nerve fibers and causes disruption in axonal signal transmission. Demyelinating Optic Neuritis (ON) is often a manifestation of MS and involves inflammation of the optic nerve. ON can cause vision loss, pain and discomfort in the eyes, and difficulties in color perception.In this study, we developed NeuroVEP, a portable, wireless diagnostic system that delivers visual stimuli through a smartphone in a headset and measures evoked potentials at the visual cortex from near the O1, Oz, O2, O9 and O10 locations on the scalp (extended 10-20 system) using custom electroencephalography (EEG) electrodes.

Authors

  • S Mohammad Ali Banijamali
    Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
  • Craig Versek
    NeuroFieldz Inc, Newton, MA, USA.
  • Kristen Babinski
    Department of Neurology, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA.
  • Sagar Kamarthi
    Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
  • Deborah Green-LaRoche
    Department of Neurology, Tufts University School of Medicine, Tufts Medical Center, Boston, MA, USA.
  • Srinivas Sridhar
    Department of Physics, Department of Bioengineering and Department of Chemical Engineering, Northeastern University, Boston, MA 02115, NeuroFieldz Inc, Newton, MA, USA.

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