Biosynthesis of Quercetin-Loaded Melanin Nanoparticles for Improved Antioxidant Activity, Photothermal Antimicrobial, and NIR/pH Dual-Responsive Drug Release.

Journal: Foods (Basel, Switzerland)
Published Date: Nov 23, 2023

Abstract

Quercetin (QCT) is a promising dose-dependent nutraceutical that usually suffers from poor water solubility and low bioavailability issues. In this work, a novel QCT-loaded nanoscale delivery system was constructed based on the oxidative self-polymerization of melanin (Q@MNPs). The FT-IR, XRD, and Zeta potential analyses confirmed that QCT was successfully absorbed on the melanin nanoparticles (MNPs) via Π-Π and hydrogen bonding interactions. The encapsulation efficiency and particle size of Q@MNPs were 43.78% and 26.68 nm, respectively. Q@MNPs improved the thermal stability of QCT and the antioxidant properties in comparison to MNPs. Meanwhile, Q@MNPs presented fantastic photothermal conversion capacity and stability triggered by the NIR laser, which significantly enhanced the antibacterial capability with a sterilization rate of more than 98% against and . More importantly, Q@MNPs exhibited NIR/pH dual-responsive drug release behavior and good biocompatibility (at concentrations of < 100 μg/mL). Thus, Q@MNPs show promising prospects for flavonoid delivery.

Authors

  • Di Zhang
    College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Xianrui Chen
    College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Nitong Bu
    College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Liying Huang
    College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Huanglong Lin
    College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Lizhen Zhou
    College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Ruojun Mu
    College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Lin Wang
    Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China.
  • Jie Pang
    College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

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