Quantification of Early Neonatal Oxygen Exposure as a Risk Factor for Retinopathy of Prematurity Requiring Treatment.

Journal: Ophthalmology science
Published Date: Oct 22, 2021

Abstract

PURPOSE: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness related to oxygen exposure in premature infants. Since oxygen monitoring protocols have reduced the incidence of treatment-requiring ROP (TR-ROP), it remains unclear whether oxygen exposure remains a relevant risk factor for incident TR-ROP and aggressive ROP (A-ROP), a severe, rapidly progressing form of ROP. The purpose of this proof-of-concept study was to use electronic health record (EHR) data to evaluate early oxygen exposure as a predictive variable for developing TR-ROP and A-ROP.

Authors

  • Jimmy S Chen
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon.
  • Jamie E Anderson
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon.
  • Aaron S Coyner
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon.
  • Susan Ostmo
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon.
  • Kemal Sonmez
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon.
  • Deniz Erdogmus
    Department of Electrical and Computer Engineering, Northeastern University, Boston, Massachusetts.
  • Brian K Jordan
    Department of Neonatology, Oregon Health and Science University, Portland, Oregon.
  • Cynthia T McEvoy
    Department of Neonatology, Oregon Health and Science University, Portland, Oregon.
  • Dmitry Dukhovny
    Department of Neonatology, Oregon Health and Science University, Portland, Oregon.
  • Robert L Schelonka
    Department of Neonatology, Oregon Health and Science University, Portland, Oregon.
  • R V Paul Chan
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois.
  • Praveer Singh
    Department of Radiology, MGH/Harvard Medical School, Charlestown, Massachusetts.
  • Jayashree Kalpathy-Cramer
    Department of Radiology, MGH/Harvard Medical School, Charlestown, Massachusetts.
  • Michael F Chiang
    National Eye Institute, National Institutes of Health, Bethesda, Maryland.
  • J Peter Campbell
    Department of Ophthalmology, Oregon Health and Science University, Portland, Oregon.

Keywords

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