Is Blood Loss Greater in Elderly Patients under Antiplatelet or Anticoagulant Medication for Cervical Spine Injury Surgery? A Japanese Multicenter Survey.

Journal: Spine surgery and related research
Published Date: Dec 27, 2021

Abstract

INTRODUCTION: In elderly patients with cervical spinal cord injury, comorbidities such as cardiovascular and cerebrovascular diseases are common, with frequent administration of antiplatelet/anticoagulant (APAC) drugs. Such patients may bleed easily or unexpectedly during surgery despite prior withdrawal of APAC medication. Few reports have examined the precise relationship between intraoperative blood loss and history of APAC use regarding surgery for cervical spine injury in the elderly. The present multicenter database survey aimed to answer the question of whether the use of APAC drugs affected the amount of intraoperative blood loss in elderly patients with cervical spinal cord trauma.

Authors

  • Masashi Uehara
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
  • Shota Ikegami
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
  • Takashi Takizawa
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
  • Hiroki Oba
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
  • Noriaki Yokogawa
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa, Japan.
  • Takeshi Sasagawa
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa, Japan.
  • Kei Ando
    Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Hiroaki Nakashima
    Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Naoki Segi
    Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Toru Funayama
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Fumihiko Eto
    Department of Orthopaedic Surgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
  • Akihiro Yamaji
    Department of Orthopaedic Surgery, Ibaraki Seinan Medical Center Hospital, Sashima, Japan.
  • Kota Watanabe
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
  • Satoshi Nori
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
  • Kazuki Takeda
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan.
  • Takeo Furuya
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba, Japan.
  • Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba, Japan.
  • Hideaki Nakajima
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences University of Fukui, Yoshida, Japan.
  • Tomohiro Yamada
    Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  • Tomohiko Hasegawa
    Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
  • Yoshinori Terashima
    Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan.
  • Ryosuke Hirota
    Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan.
  • Hidenori Suzuki
    Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan.
  • Yasuaki Imajo
    Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan.
  • Hitoshi Tonomura
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Munehiro Sakata
    Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Ko Hashimoto
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Yoshito Onoda
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Kenichi Kawaguchi
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Yohei Haruta
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Nobuyuki Suzuki
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Kenji Kato
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Hiroshi Uei
    Department of Orthopaedic Surgery, Nihon University Hospital, Tokyo, Japan.
  • Hirokatsu Sawada
    Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan.
  • Kazuo Nakanishi
    Department of Orthopedics, Traumatology and Spine Surgery, Kawasaki Medical School, Kurashiki, Japan.
  • Kosuke Misaki
    Department of Orthopedics, Traumatology and Spine Surgery, Kawasaki Medical School, Kurashiki, Japan.
  • Hidetomi Terai
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Koji Tamai
    Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
  • Eiki Shirasawa
    Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
  • Gen Inoue
    Department of Orthopaedic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
  • Kenichiro Kakutani
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Yuji Kakiuchi
    Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Katsuhito Kiyasu
    Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, Nankoku, Japan.
  • Hiroyuki Tominaga
    Department of Orthopaedic Surgery, Kagoshima University, Kagoshima, Japan.
  • Hiroto Tokumoto
    Department of Orthopaedic Surgery, Kagoshima University, Kagoshima, Japan.
  • Yoichi Iizuka
    Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • Eiji Takasawa
    Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Japan.
  • Koji Akeda
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
  • Norihiko Takegami
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
  • Haruki Funao
    Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare, Narita, Japan.
  • Yasushi Oshima
    Department of Orthopaedic Surgery, The University of Tokyo Hospital, Tokyo, Japan.
  • Takashi Kaito
    Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
  • Daisuke Sakai
    Department of Orthopedics Surgery, Surgical Science, Tokai University School of Medicine, Isehara, Japan.
  • Toshitaka Yoshii
    Department of Orthopedics, Tokyo Medical and Dental University, Tokyo, JPN.
  • Tetsuro Ohba
    Department of Orthopaedic Surgery, University of Yamanashi, Yamanashi, Japan.
  • Bungo Otsuki
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
  • Shoji Seki
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, Toyama, Japan.
  • Masashi Miyazaki
    Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Yufu, Japan.
  • Masayuki Ishihara
    Department of Orthopaedic Surgery, Kansai Medical University Hospital, Hirakata, Japan.
  • Seiji Okada
    Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
  • Yasuchika Aoki
    Department of Orthopaedic Surgery, Eastern Chiba Medical Center, Togane, Japan.
  • Katsumi Harimaya
    Department of Orthopaedic Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
  • Hideki Murakami
    Department of Orthopaedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Ken Ishii
    Department of Orthopaedic Surgery, School of Medicine, International University of Health and Welfare, Narita, Japan.
  • Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba, Japan.
  • Shiro Imagama
    Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Satoshi Kato
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa, Japan.

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