Preoperative soluble cluster of differentiation 40 ligand level is associated with outcome of pulmonary endarterectomy.

Journal: JTCVS open
Published Date: Oct 21, 2021

Abstract

OBJECTIVE: Soluble CD40 ligand (sCD40L) is associated with some pathobiological states. However, whether sCD40L in patients with chronic thromboembolic pulmonary hypertension (CTEPH) who underwent pulmonary endarterectomy (PEA) is associated with perioperative pulmonary hemodynamics and surgical outcomes has not been elucidated. Here we aimed to investigate whether sCD40L is a useful serologic biomarker of poor surgical outcome of PEA in patients with CTEPH.

Authors

  • Ayako Shigeta
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Nobuhiro Tanabe
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Akira Naito
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Hajime Yokota
    Department of Radiology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Fumiaki Kato
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Takayuki Jujo-Sanada
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Seiichiro Sakao
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Keiichi Ishida
    Department of Cardiovascular Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Masahisa Masuda
    Department of Cardiovascular Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
  • Koichiro Tatsumi
    Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.

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