Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study.

Journal: Journal of clinical and translational hepatology
Published Date: Sep 18, 2021

Abstract

BACKGROUND AND AIMS: The natural course of chronic hepatitis B virus (HBV) infection is widely studied; however, follow-up studies of the same patients are scanty. Here, we studied the dynamic changes of serum HBV RNA and cytokines in hepatitis B virus e antigen (HBeAg)-positive patients treated with entecavir (ETV) to explore the relationship between the HBV serum viral nucleic acids and host immunity.

Authors

  • Qiqi Zhang
    Department of Biobank, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Hui Huang
    Department of Biobank, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Aijun Sun
    Outpatient Department of Hepatitis, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Chunyan Liu
    Chengdu Kuafu Technology Co., Ltd., Chengdu 610100, China.
  • Zhidong Wang
    Department of Pathology, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Feifan Shi
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
  • Wei Duan
    School of Medicine, Deakin University, Victoria, Australia.
  • Xueying Sun
    Department of Biobank, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Qi Wang
    Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Ping Sun
    Department of Pathology, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Chunwen Pu
    Department of Biobank, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Yong Zhang
    Outpatient Department of Hepatitis, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.

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