Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells.

Journal: Bioinformation
Published Date: Aug 31, 2021

Abstract

It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor receptors-2 (HER2) were studied using RT-PCR analysis and western blot analysis. The results show significant cell growth inhibition with minimal IC50 values of 46.25 ± 0.42 micro g/mL against A2780 cell lines. mRNA and protein expression were considerably reduced in treated A2780 cell lines for further consideration as a chemotherapeutic agents.

Authors

  • Chella Perumal Palanisamy
    State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China.
  • Sivakumar Pethanan
    Department of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
  • Gopinath Gurulingam Vincent
    Department of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
  • Karthigeyan Murugesan
    Department of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
  • Ananthavalli Ramachandran
    Department of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
  • Ramu Sivanandam
    Department of zoology, Arumugam Pillai Seethai Ammal College, Tiruppathur, Tamil Nadu, India.
  • Mani Panagal
    Department of Biotechnology, Annai College of Arts and Science, Kovilacheri, Kumbakonam, Tamil Nadu - 612503, India.

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